Synthesis of 8-Hydroxypurine Nucleosides

Cytidine nucleosides II. Photochemical synthesis of 5-alkylcytidine nucleosides

5-Alkylcytidine nucleosides were synthesized via a photocoupling reaction. 5-Propylcytidine and 5-propyl-2-deoxycytidine have been prepared through the reduction of 5-(3-propenyl)cytidine and its 2'-deoxy derivative, which in turn were prepared by photoirradiation of cytidine or 2'-deoxycytidine in the presence of 3-iodopropene. 5-(2-Hydroxyethyl)cytidine and its derivatives were obtained from ...

Prebiotic Synthesis of Pyrimidine Nucleosides

Oligonucleotides incorporating 8-aza-7-deazapurines: synthesis and base pairing of nucleosides with nitrogen-8 as a glycosylation position.

Oligonucleotides incorporating the unusually linked 8-aza-7-deazapurine N8-(2'-deoxyribonucleosides) 3a,b (purine and 6-amino-2-chloropurine analogues) were used as chemical probes to investigate the base pairing motifs of the universal nucleoside 8-aza-7-deazapurin-6-amine N8-(2'-deoxyribofuranoside) 2 (adenine analogue) and that of the 2,6-diamino compound 1. Owing to the absence of an amino ...

Synthesis of O-Amino Sugars and Nucleosides.

Nucleic acids and carbohydrates are essential biomolecules involved in numerous biological and pathological processes. Development of multifunctional building blocks based on nucleosides and sugars is in high demand for the generation of novel oligonucleotide mimics and glycoconjugates for biomedical applications. Recently, aminooxyl-functionalized compounds have attracted increasing research i...

Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis

Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes. Some of these nucleosides have been obtained from a variety of marine resources. Because of the biological importance of these compounds, this review cove...